- - Seahawks vs. 49ers odds, picks, predictions: Best bets for NFL divisional round game

Ben FawkesMatt Russell and Matt JacobJanuary 16, 2026 at 1:00 AM

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The NFC West champion and No. 1-seeded Seattle Seahawks will host the San Francisco 49ers on Saturday in the third meeting between the two teams this season. The Seahawks beat the 49ers 13-3 in Week 18 to clinch the NFC West and the conference's top seed, so they got to rest at home while San Francisco impressively went on the road and defeated the Philadelphia Eagles 23-19 as a 5.5-point underdog.

Can Kyle Shanahan win another game as a big underdog? Will Sam Darnold overcome his issues in big games to lead Seattle to the NFC championship game?

Here is insight from oddsmakers for the game, and our team of NFL handicappers provides its favorite wagers on the game.

Odds courtesy of BetMGM.

No. 6 San Francisco 49ers at No. 1 Seattle Seahawks (-7, 45)What oddsmakers are saying

"I did add the 49ers to my Christmas list for next year after they eliminated the Eagles for us. Losing George Kittle is huge, as they’ve basically been a MASH unit all season. We opened Seattle -6.5, it was quickly bet up to -7 and touched -7.5. Now we’re back down to -7. Pretty good two-way action. Total has come down from 46.5 down to 45. Sharp action on the total pushing it down. Seattle is our best-case scenario for futures, both Super Bowl and NFC, and 49ers aren’t bad either. The only team we have liability left on is the Rams." — Thomas Gable, sportsbook director at The Borgata

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"Last week, we saw an unprecedented move with sharps betting Eagles from -3.5 to -6 before some buyback brought it -5.5. The thought was that the 49ers were beat up and there’d be some weather and they couldn’t compete — and that was not the case. We opened this game at Seahawks -7, briefly hit -7.5, now back down to -7. Seeing a lot of 49ers moneyline wagers and to cover +7.5. Big number for a divisional game." — Joey Feazel, head of NFL trading at Caesars Sportsbook

Best bets

Matt Jacob: Total points scored when the Seahawks and 49ers squared off for a second time last season: 37.

Total points scored when these NFC West rivals met in the 2025 season opener in Seattle: 30.

Total points scored in the 2025 regular season finale in San Francisco: 16.

In fact, seven of the last nine head-to-head meetings have fallen short of 45 combined points.

Yes, the Niners’ defense has gotten picked apart at times this season — from Weeks 15-17, they surrendered 89 points to Caleb Williams, Philip Rivers and Cam Ward. But that defense came up huge against the defending Super Bowl champs last week and did it on the road.

And in two games against the Seahawks, San Francisco surrendered just two touchdowns and four field goals.

Meanwhile, Seattle had the NFL’s No. 1 scoring defense in the regular season, allowing just 17.2 points per game. What’s more, if you take out a wild 38-37 overtime win over the explosive Rams, here are the point totals produced by the last four visitors to Seattle: 19 (Texans), 22 (Cardinals), 0 (Vikings) and 16 (Colts).

Bet: Under 45 total points (-110)

Russell: Part and parcel with the under is that operation No. 1 for the Seahawks is to manage Darnold’s exposure to potential turnovers, because generating multiple interceptions or strip-sack of the quarterback is the only way the 49ers can win this game.

Normally, the team that won the last matchup has to worry about having to change something in order to stay ahead of the adjustments that the losing team is going to make, but Seattle’s Week 18 performance was so basic that it can replicate its success on the ground. After all, it wasn’t an anomaly that San Francisco would get gashed on the ground, as the Bears ran well the week before, and Saquon Barkley had a rare 100-yard game this season in the wild-card game, the week after Seattle’s tailback duo combined for 171 yards on 33 carries in Week 18.

Which running back will clear his various prop totals is tough to parse, so instead we’ll bet that Darnold isn’t asked to do much, and that the 49ers’ defense will continue its plan to keep everything in front of it, hoping to get stops in the red zone. With explosiveness unnecessary and unlikely, we’ll fade Darnold’s yardage total, in a backhanded compliment to the Seahawks' chances of winning.

Bet: Sam Darnold under 236.5 passing yards (-115)

Jacob: Two weeks ago against the Seahawks, Christian McCaffrey touched the pigskin 17 times and produced a total of 57 scrimmage yards. Not only was McCaffrey playing at home, but 49ers teammate (and perennial Pro Bowler) George Kittle was on the field drawing the attention of the Seahawks’ linebackers and defensive backs.

This week, McCaffrey travels to Seattle and Kittle won’t be anywhere near the field after tearing his Achilles last week in Philadelphia. In other words, CMC will be public enemy No. 1 (and Nos. 2 and 3) for Seattle’s dominant defense.

Of course, McCaffrey will get plenty of opportunities to duplicate last week’s performance in Philadelphia (21 touches, 114 total yards). Not only because of his dual-threat skills, but also because 49ers quarterback Brock Purdy doesn’t have a ton of other options.

Still, even if McCaffrey gets his hands on the ball 25 times, can you really envision him doubling the numbers he produced against Seattle in Week 18? Especially when facing a defense whose rallying cry this week has to be “Anybody but McCaffrey?”

I sure can’t.

Bet: Christian McCaffrey under 107.5 rushing and receiving yards (-105)

Feng: Purdy has been excellent this season. When I take his yards per pass attempt and adjust for opposing defenses, Purdy is expected to throw for 6.95 YPPA against an average NFL defense, fifth-best among starters. However, he faces an elite Seattle defense that ranks third in these same numbers. My model based on adjusted YPPA predicts 219 passing yards for Purdy, and it should be even less without Kittle and likely WR Ricky Pearsall.

Purdy effectively didn’t have both receivers last week — Kittle got hurt on his second target — but he still threw for 262 yards against an excellent Philadelphia defense. That performance is probably propping this number up.

Bet: Brock Purdy under 229.5 passing yards

Original Article on Source

Source: “AOL Sports”